跳到主要內容區

蔡少正校長

校長 蔡少正 博士

Dr. Shaw-Jenq Tsai

學歷

  • 成功大學 學士，1982-1986
  • 美國東密西根大學 碩士，1990-1992
  • 美國威斯康辛大學 博士，1993-1997
  • 美國威斯康辛大學 博士後研究，1997-1998

 

經歷

  • 成大生理所 助理教授，1998-2002
  • 成功大學生物資訊中心 負責人，2001-2024
  • 成大生理所 副教授，2002-2005
  • 成大生理所 教授，2005-2008
  • 成大生理所 教授兼所長，2006-2009
  • 成大生理所 特聘教授，2008-2019
  • 成大生理所 講座教授，2019-2024
  • 美國休士頓貝勒醫學院 訪問教授，2010-2011
  • 科技部生科司 司長，2014-2017
  • 中國生理學會 理事長，2016-2020
  • 亞洲子宮內膜異位症及肌腺症學會會長，2019-2020
  • 亞洲區主編 實驗生物學及醫學期刊，2012-迄今
  • 資深編輯委員 分子內分泌學期刊，2020-迄今
  • 資深編輯委員 內分泌學期刊，2020-迄今
  • 總編輯 生理學研究期刊，2024-迄今

主要榮譽與獎勵

  • 國科會傑出研究獎(2011)
  • 美國實驗生物醫學學會傑出科學家獎(2014)
  • 科技部傑出研究獎(2018)
  • 美國實驗生物醫學學會：會士(2018)
  • 美國癌症研究學會最佳被引用論文(2019)
  • 美國生殖研究學會傑出國際科學家獎(2021)
  • 教育部第65屆學術獎(2022)
  • 國際生理學聯盟 院士 (2022)

專長學科

內分泌學、癌症及轉譯醫學、生物資訊學、表觀遺傳學、子宮內膜異位症

相關著作（自2014..）

  1. HT Hou, TC Lin, MH Wu, SJ Tsai* Feel so bac: is Fusobacterium the suspect causing endometriosis? Trends Mol Med.29 (10):780-782, 2023. https://doi.org/10.1016/j.molmed.2023.08.003.
  2. T Harada, F Taniguchi, SW Guo, YM Choi, KO Biberoglu, SJ Tsai, S Alborzi , M Al-Jefout, A Chalermchokcharoenkit, A Sison-Aguilar, YF Fong, H Senanayake, A Popov, A Hestiantoro, Y Kaufmann The Asian society of endometriosis and adenomyosis (ASEA) guidelines for managing adenomyosis. Reprod Med Biol Jan-Dec; 22(1): e12535 2023.
  3. CB Chu, CC Yang, YY Hsueh, PC Chen, YK Hong, YY Kuo, S-J Tsai* Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa. Br J Dermatol 189(6):719-729, 16 Nov,2023. DOI: 10.1093/bjd/ljad273. 
  4. SC Lin, WN Li, SC Lin, HT Hou, YC Tsai, TC Lin, MH Wu*, SJ Tsai* Targeting YAP1 ameliorates progesterone resistance in endometriosis. Hum Reprod 38 (6), 1124-1134, 1 June 2023. DOI: 10.1093/humrep/dead071.
  5. PL Hsu, CW Chien, YA Tang, BW Lin, SC Lin, YS Lin, SY Chen, HS Sun*, SJ Tsai* Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis. Sci Adv 9(15): eade3422, 12 Apr 2023. DOI: 10.1126/sciadv.ade3422.
  6. YS Lai CC Chang YY Chen TMH Nguyen J Xu YC Chen YF Chang CY Wang PS Chen SC Lin IC Peng SJ Tsai WT Chiu* Optogenetically engineered Ca2+ oscillation-mediated DRP1 activation promotes mitochondrial fission and cell death. J Cell Sci136(12): jcs260819, 15 June, 2023. DOI: doi.org/10.1242/jcs.260819.
  7. YY Chao, BM Huang, IC Peng, PR Lee, YS Lai, WT Chiu, YS Lin, SH Lin, JH Chang, PS Chen, SJ Tsai*, CY Wang* ATM-ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma. J Cell Physiol, 237(12):4487–4503, 2022.
  8. C.B. Chu, C.C. Yang, S.J. Tsai* Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chin J Physiol 64(6):257-265, Nov-Dec 2021, doi: 10.4103/cjp.cjp_67_21.
  9. C.B. Chu, C.C. Yang*, W.L. Li., S.H. Lin, C.K. Hsu, S.J. Tsai* The influence of gender and smoking on hidradenitis suppurativa -A retrospective study of 161 patients in Taiwan. Dermatologica Sinica 39:125-31, - July 2021
  10. C.B. Chu, C.C. Yang, S..J. Tsai* Global data analysis supports smoking as the fundamental element associated with geographic gender disparities in hidradenitis suppurativa. Br J Dermatol 185(5):1054-1056, June 2021 https://doi.org/10.1111/bjd.20581.
  11. CA Wang, CF Li, RC Huang, PC Hou, JP Liou, SJ Tsai* Suppression of extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination by a selective HDAC1/2 inhibitor. Mol Cancer Ther 20(9):1550-1560; doi: 10.1158/1535-7163.MCT-20-0963, 2021.
  12. CA Wang, and SJ Tsai* Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis. Exp Biol Med (Maywood), 246(19):2048-2056, June 2021
  13. PH Yu, PY Chou, WN Li, SJ Tsai, MH Wu* The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis. Taiwan J Obstet Gynecol 60(4):711-717,Jul 2021
  14. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* FGF9 induces neurite outgrowth upon ERK signaling in knock-in striatal Huntington's disease cells., Life Sci 267, 118952, 15 Feb 2021.
  15. IO Yusuf, HM Chen, PH Cheng, CY Chang, SJ Tsai, JI Chuang, CC Wu, BM Huang, HS Sun, CM Chen, SH Yang* Fibroblast growth factor 9 stimulates neuronal length through NF-kB signaling in striatal cell Huntington’s disease models. Mol Neurobiol 58 (5): 2396-2406, May 2021.
  16. WN Li, MH Wu, SJ Tsai* HYPOXIA AND REPRODUCTIVE HEALTH: The role of hypoxia in the development and progression of endometriosis. Reproduction 161 (1): F19-F31, 2021. doi: 10.1530/REP-20-0267
  17. HC Lee, SC Lin, MH Wu, SJ Tsai* Inhibiting NTRK2 signaling causes endometriotic lesion regression. Reproduction 161(1):11-19, 2021 Jan; doi: 10.1530/REP-20-0163.
  18. YS Lai, YH Chang, YY Chen, J Xu, CS Yu, SJ Chang, PS Chen, SJ Tsai, WT Chiu* Ca2+-regulated cell migration revealed by optogenetically engineered Ca2+ oscillations. J Cell Physiol 26 Nov, 2020. doi: 10.1002/jcp.30190
  19. YH Li, TM Chen, BM Huang, SH Yang, CC Wu, YM Lin, JI Chuang, SJ Tsai, HS Sun* FGF9 is a downstream target of SRY and sufficient to determine male sex fate in ex vivo XX gonad culture. Biol Reprod 103 (6):1300-1313, 1 Dec, 2020
  20. WN Li, KY Hsiao, CA Wang, N Chang, PL Hsu, CH Sun, SR Wu, MH Wu*, SJ Tsai* Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis. Proc Natl Acad Sci U S A, 117 (41): 25859-25868, 13 Oct, 2020. doi.org/10.1073/pnas.1920037117
  21. PS Chen, WT Chiu, PL Hsu, SC Lin, IC Peng, CY Wang, SJ Tsai* Pathophysiological implications of hypoxia in human diseases. J Biomed Sci 27: 63, 11 May 2020. doi.org/10.1186/s12929-020-00658-7
  22. S Koks*, RW Williams, J Quinn, F Farzaneh, N Conran, SJ Tsai, G Awandare, SR Goodman COVID-19: Time for precision epidemiology. Exp Biol Med (Maywood). 245 677-679. Apr 2020, DOI: 10.1177/1535370220919349
  23. CA Wang, YH Chang, PC Hou, YJ Tai, WN Li, PL Hsu, SR Wu, CF Li, YS Shan, SJ Tsai* DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. J Extracell Vesicles 9 (1): 1746529, 4 April 2020. DOI: 10.1080/20013078.2020.1746529
  24. PS Chen, SC Lin, SJ Tsai* Complexity in regulating microRNA biogenesis in cancer. Exp Biol Med 245:395-401,March 2020 DOI: 10.1177/1535370220907314
  25. CH Lai, RY Chen, HP Hsieh, SJ Tsai, KC Chang, CJ Yen, YC Huang, YW Liu, JC Lee, YC Lai, LY Hung, BW Lin A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis. Cancer Lett 472:97-107, 1 Mar 2020; doi: 10.1016/j.canlet.2019.12.031.
  26. HC Lee, SC Lin, MH Wu*, SJ Tsai* Induction of pyruvate dehydrogenase kinase 1 by hypoxia alters cellular metabolism and inhibits apoptosis in endometriotic stromal cells. Reprod Sci 26 (6):734-744. doi: 10.1177/193371911878951, Jun; 2019.
  27. Wu, M.H., Hsiao, K.Y., and *Tsai, S. J. Hypoxia: The force of endometriosis. J Obstet Gynaecol Res 45, (3), pp. 532-541,2019 PMID: 30618168
  28. Lin, S.C., Lee, H.C., Hsu, C.T., Huang, Y.H., Li, W.N., Hsu, P.L., Wu, M.H., and *Tsai, S.J. (2019) Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression, Theranostics 9, (3) 620-632 PMID: 30809297
  29. Hsu, P.L., Jou, J., and *Tsai, S.J.: ‘TYRO3: A potential therapeutic target in cancer’, Exp Biol Med (Maywood), 2019, 244, (2), pp. 83-99 PMID:30714403
  30. Chen, T.M., Lai, M.C., Li, Y.H., Chan, Y.L., Wu, C.H., Wang, Y.M., Chien, C.W., Huang, S.Y., Sun, H.S., and *Tsai, S.J.hnRNPM induces translation switch under hypoxia to promote colon cancer development, EBioMedicine, 2019 PMID: 30852162
  31. Chen, T.M., Chen, Y.H., Sun, H.S., and *Tsai, S.J.Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis, Chin J Physiol, 2019 62 (1)2-10, 2019 DOI: 10.4103/CJP.CJP_11_19
  32. Fu, J.L., Hsiao, K.Y., Lee, H.C., Li, W.N., Chang, N., Wu, M.H., and *Tsai, S.J.: ‘Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis’, Hum Reprod,33, (8), 1517-1527,2018 PMID: 29982401
  33. Li, W.N., Wu, M.H., and *Tsai, S.J.Critical Factors Involved in Chronic Inflammation in the Pathophysiology of Endometriosis. Adaptive Med, 10(1): 1-9, 2018DOI: 10.4247/AM.2018.ABI197
  34. Brown, D.M., Lee, H.C., Liu, S., Quick, C.M., Fernandes, L.M., Simmen, F.A., Tsai, S.J., and Simmen, R.C.M.: ‘Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis’, J Endocr Soc,2, (7), 765-778, 2018 PMID: 30151432
  35. Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S., and *Tsai, S. J.Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer Res, 77, 4305-4316, 2017 PMID: 28652251
  36. Lin, S. C., Lee, H. C., Hou, P. C., Fu, J. L., Wu, M. H., and *Tsai, S. J.Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising maternal fertility. J Pathol, 242, 476-487,2017 PMID: 28608501
  37. Hsiao, K. Y., Lin, Y. C., Gupta, S. K., Chang, N., Yen, L., Sun, H. S., and *Tsai, S. J.Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Cancer Res, 77, 2339-2350,2017 PMID: 28249903
  38. Lin, S. C., Hsiao, K. Y., Chang, N., Hou, P. C., and *Tsai, S. J.Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer. J Pathol, 241, 638-648,2017 PMID: 28026024
  39. Lin, S. C., Kao, C. Y., Lee, H. J., Creighton, C. J., Ittmann, M. M., Tsai, S. J., Tsai, S. Y., and Tsai, M. J. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun 7, 11418,2016 PMID: 27108958
  40. Lai, M. S., Wang, C. Y., Yang, S. H., Wu, C. C., Sun, H. S., Tsai, S. J., Chuang, J. I., Chen, Y. C., and Huang, B. M. The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis,12, 61-77 PMID, 2016: 27078042
  41. Chien, C. W., Hou, P. C., Wu, H. C., Chang, Y. L., Lin, S. C., Lin, S. C., Lin, B. W., Lee, J. C., Chang, Y. J., Sun, H. S., and ＊ Tsai, S. J. Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene, 35, 5872-81, 2016PMID: 27132510
  42. Wang, C. A., and ＊ Tsai, S. J. The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood), 240, 718-724,2015 PMID: 25888649
  43. Liang, K. C., Tseng, J. T., Tsai, S. J., and Sun, H. S. Characterization and distribution of repetitive elements in association with genes in the human genome. Comput Biol Chem, 57, 29-38, 2015 PMID: 25748288
  44. Hsiao, K. Y., Wu, M. H., Chang, N., Yang, S. H., Wu, C. W., Sun, H. S., and ＊ Tsai, S. J. Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Mol Hum Reprod, 21, 894-904, 2015 PMID: 26433194
  45. Hsiao, K. Y., Lin, S. C., ＊ Wu, M. H., and ＊ Tsai, S. J. Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed)7, 309-321, 2015 PMID: 25553382
  46. Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M., and Yang, S. H. The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One 10, e0137637, 2015 PMID: 26376480
  47. Chuang, J. I., Huang, J. Y., Tsai, S. J., Sun, H. S., Yang, S. H., Chuang, P. C., Huang, B. M., and Ching, C. H. FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med 89, 274-286, 2015 PMID: 26424114
  48. Tang, Y. T., Kao, H. Y., Tsai, S. J., and Wang, H. C. A semi-supervised, weighted pattern-learning approach for extraction of gene regulation relationships from scientific literature. Int J Data Min Bioinform 9, 401-416, 2014 PMID: 25757247
  49. Lin, S. C., Liao, W. L., Lee, J. C., and ＊ Tsai, S. J. (2014) Hypoxia-regulated gene network in drug resistance and cancer progression. Exp Biol Med (Maywood)239, 779-792 PMID: 24812122
  50. Lin, S. C., Li, Y. H., Wu, M. H., Chang, Y. F., Lee, D. K., Tsai, S. Y., Tsai, M. J., and ＊ Tsai, S. J. Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab 99, E427-437, 2014 PMID: 24423359
  51. Liao, W.-L., Lin, S.-C., Sunny Sun, H., and ＊ Tsai, S. J . Hypoxia-induced tumor malignancy and drug resistance: Role of microRNAs.Biomarkers and Genomic Medicine 6, 1-11,2014  http://dx.doi.org/10.1016/j.bgm.2014.01.003
  52. Lai, M. S., Cheng, Y. S., Chen, P. R., Tsai, S. J., and Huang, B. M. (2014) Fibroblast growth factor 9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse Leydig cells. PLoS One 9, e90243 PMID: 24603862
  53. Chen, T. M., Shih, Y. H., Tseng, J. T., Lai, M. C., Wu, C. H., Li, Y. H.,  *Tsai, S. J. , and ＊ Sun, H. S. Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res 42, 2932-2944, 2014 PMID: 24334956
登入成功